What we are researching right now.

Being briefed and drafted right now.

1. 01

   GLP-1s during pregnancy and the conversations no one is having

   The labels say discontinue at least two months before a planned pregnancy, but readers ask us about unplanned ones every week.

   Lands in Lifestyle
2. 02

   Slow-dose protocols: when prescribers hold you at 0.25mg longer

   Off-label step-down practice is real and rarely written about calmly.

   Lands in Side effects
3. 03

   Wegovy and alcohol, what the receptor work actually shows

   Reduced reward signalling shows up in animal models and small human trials, and readers feel it.

   Lands in Lifestyle
4. 04

   Mounjaro vs Zepbound: same drug, different contracts, different prices

   Tirzepatide is one molecule with two FDA approvals. Readers want a calm, cited comparison without the telehealth pitch.

   Lands in GLP-1 101
5. 05

   How to actually keep muscle on a GLP-1, the Phillips & Trommelen reading

   Most muscle-preservation advice online is borrowed from bodybuilding. The trial literature is more specific and more useful.

   Lands in Food & muscle
6. 06

   Oral semaglutide vs the injectable, Rybelsus, side effects, and the absorption question

   The pill is real and underdiscussed. The dosing window matters.

   Lands in GLP-1 101
7. 07

   GLP-1s and a thyroid-cancer history, what the boxed warning means and doesn't

   Rodent C-cell findings drive the label. We want a calm, cited reading.

   Lands in Side effects
8. 08

   Cycling off and the rebound question, STEP-4, SURMOUNT-4, and what comes next

   The trial data on stopping is now strong enough to be specific about. Most coverage is still vague.

   Lands in Long-term

Lined up next.

• Sulfur burps on Ozempic: why they happen and what helpsSide effects
• GLP-1s and gallbladder disease, what to watch forSide effects
• Hair shedding on a GLP-1, what's the drug, what's the calorie deficit, what helpsSide effects
• The protein math: how much, when, and why the timing argument is overblownFood & muscle
• What to put on the plate when nothing sounds goodFood & muscle
• Resistance training on a GLP-1, the minimum effective doseFood & muscle
• Travel kit for a GLP-1, the four things that actually matterLifestyle
• Dating on a GLP-1, the awkwardness of restaurants when nothing sounds goodLifestyle
• The food-noise question, what the dopamine literature actually saysLifestyle
• Maintenance dosing, 0.5mg, every other week, or something elseLong-term
• The plateau at month 9, what's normal, what's not, what to ask forLong-term
• Coming off a GLP-1: the four-week taper most prescribers don't mentionLong-term
• Compound semaglutide and tirzepatide, what the FDA shortage list actually meansGLP-1 101
• Insurance coverage in 2026, what actually changedGLP-1 101
• GLP-1s and hormonal contraception, the absorption questionLifestyle
• GLP-1s for non-diabetic type-2 prevention, what the trials showGLP-1 101
• The constipation stack, the four things that actually move the needleSide effects
• Acid reflux and GERD on a GLP-1, separating the drug from the food choicesSide effects
• Sleep on a GLP-1, what readers report and what the literature showsLifestyle
• Bone density on long-term GLP-1 useLong-term
• GLP-1s and PCOS, what's actually been studiedGLP-1 101
• When the scale won't move at all, the under-eating trapLong-term
• GLP-1s after 60, what changes in dosing, monitoring, and foodLong-term

Tell us what we are missing.

The best questions on this list came from readers. Send us a question and it goes into the queue.